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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2f420a5716b99218d4ce817e331d6b3a30c48c35a6b262bfe720223b2a0e7fb0' 
  AND token = 'JaYycjp3yzC1t/x3COKKo/ELHk0XGrgZ+QGd6SP+WW8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}