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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '0fb49fcfb7aa8e6bf9810e7ac36ffacf018c846adfd5b23456fe48278919b4b1' 
  AND token = 'FUxABNx/6aVsXCS8Cw454WsFnAVnWG8lQz7XFT1lxJw=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00027

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}