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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '46800182a55905704f12994eb1e5fe5edcdac1e15202aa81dcb3ebeb183f4187' 
  AND token = 'qAgJNsdcXVjeo9AbNAAvAY4MRG/NLrr7tRf5zbV0qoU=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}