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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'd8f8c59ce10c34963aacb16d6e50485e0ad8272084b9c83d051e8ef1ced145c1' 
  AND token = 'M2KTBFavBcFQHpLvameIkxwnoP11tms+4QmCiXlePZ0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}