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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '16f57143d3bef8b99e005a7ce2a1ef05efda1b567de60e1517239b72fe74fe3f' 
  AND token = 'XE5QzKyYCPNSshY7j9qY2ErAxGb7Ysfj0Dl8lzR60m4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00026

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}