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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2116fa2afe5dbf75bd23acb914d7ff0b2ea3811b7157a5d6c30b6e60bb9f9364' 
  AND token = 'QxWPe+oASN7d0XjqzMkoij7gQptyXGom1XVZH1LoTd8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00032

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}