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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'cb245de9fb933d0a8c66288e14f12a42b455e0e86fe3281cea8d5efe149412b6' 
  AND token = 'dfR5R2FHR1h/ncbY8ixOo7fM+QaqMfxiSe82Y/J6DRw=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}