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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '1ad0f46fbdf971f659ad692a22f98d2882f8640f5e2cd475d1f1b0641e64b6a2' 
  AND token = 'DMsemhCzDORkAW16T7Dmda1PmYk4nfy2CGp/hnkf46g=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00037

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}