SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'e8fd306caa29e7467b4e37e2d52757a85666eaad6cb8d999356fa48198101bc0' 
  AND token = 'ZHeSLD1aWChHsq1LdyqalKiAAHpNohqSMMQO29Kt/V4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00036

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}