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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '35f7bc1cabc2b36b72fc7321c52dd3e8d21a7ee732691a75426577efa2190201' 
  AND token = 'z+fo7L5VQgtU1VtZPuQxnIMI64sS/Htul7q+aIGj7Ak=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}