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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '40d360aaa69779ddb9b6b2bc594e76bc9e887ef6f78a52b5594c5bff2ec1157b' 
  AND token = 'MZZ6fFoG/bomDCon9vZG9PlD7IWj3f2ctHwaOMhLzNs=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00028

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}