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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2a51a3cf3e0a525784d049c2000194d711d489aa2e6a2e73f3105967bae6fad1' 
  AND token = 'R57bJn/XWnWjHbiOK/JqMdO75IN47gIatpMAri5pyDg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00033

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}