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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'b433e5c0058c620dc1a2f8d0eaca3d5c8314725863b56eeafbd9b042542a0799' 
  AND token = '3Idy3VV1U6rP/wjm5xz5Vn7T+T7ks2SfyY4oy3Wv5rY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}