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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '22737fd0af335642c5489f4dae479ed03b782f4738f857b426256035d468d576' 
  AND token = 'Y9Fh+6BQ6USDu/ADaumd6jDqiW6sv1oP6Xk7/CfbB48=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}