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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '8c99289696294ec74f186a1b9aa5f621ca1e5df763d81b5984fdd9f7cbe08a41' 
  AND token = 'YIi1IR/TItH+nR5k3/rHjI0XV6aEIr3UEcWN9ZccHqE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00022

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}