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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '9f5299e3619503cf1937bb299a8697e5f45f0f034bdfbd3989ab04e6d9392642' 
  AND token = 'zyW2TCPSP2gUC1KLpzvmcpRKAVGj9rLtTU1dzIRWbok=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}