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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '14465d0fcc3514d74766cdc3a9647ed3b227008ba1a9c304c926b2aa09e51db2' 
  AND token = 'X4VbSOTCgFtDWFXRUz0+HzhnD1a2s7i0/oTZWcixH0Y=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}