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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '506303b2336e0714469ed6ad23d22a482c86d5a48d01b0290c6fbb962c1a8e3c' 
  AND token = 'GYhU8WQas7GGQaqvjBKXSXQoXOlGcdhMGLz3cpDAgEk=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00027

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}