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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '44e254853ee4385e51b596cfc69d01945e670f2036203483a9f4d135c7f70173' 
  AND token = 'cLuAK9BESN2jzxUV2muLafsPCc/jvmtsHaGRWtjpkU8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00023

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}