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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '6b17c21ef82480e504130f34ad3d2489421cd12c387c5121fab63b66f22549b7' 
  AND token = '8RgjPq+zt0XoVrmzRIW3ij3sTqR9Y+c/afcpwEIy0PM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}