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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'fe6d412be4ead1a203a41deeed23e923b486c37e2bb5305b403998f98800e15a' 
  AND token = 'fwl4sNmhuLSt5kE8D8qoX3FldhSCMj8sr1ThzHbkM+0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}