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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '12d1e26f3373ede832036fa99691eb33fc09444f2e53c0fcfeea5659ca6a504e' 
  AND token = 'Z+yo4uBoEkUvgo4Yea+Tvm8x8lXqnDm1cXnrkkqhWO4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00016

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}