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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '8ad67eb8bb823cb9613630b1e9091e01fa77de60d53865b81dbeca9bbc449ec2' 
  AND token = 'A0HmfnkhUt/DR9ZNDUlaS4FM7piaCcSAC9aDjbkxpK0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00016

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}