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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4330865f50b2dc6e9ba5980ab029702e738801254be8d9cf67e2714f11b59997' 
  AND token = 'kzOf7W3JGMR0sA5DLz7/wnJPc5qUl3uoGpeMBMsP4LE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00017

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}