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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '5e0763e4c111163428468d418aefde7c99e53fd4dbb37a8f82553fb5991796a1' 
  AND token = 'wf2YOd9qkDG4JvRmaNTF1HZKNzWGDi2N0LDPDekVQc0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00017

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}