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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '43d54d8f7647f6b41ee975fde84f588d3533b2cf68980d0a2f81805e3b16c857' 
  AND token = 'p2KYNZwTTQ3hE2fSz9yNBrz4eEOV2q7Y5q9vzchiYGc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00022

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}