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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'e370c8c5e7501c33a50a7465b144e60f859fbcacdc6a65bbd5d52c29172240c4' 
  AND token = 'P+iy0ONgyJcncZk/8hR0tYCLn2d/WYkfZrh6sZsG2MM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00017

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}