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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'e1b6288243871a7628f5c4e648fc7f00eb7b48529fe505450b317449f80f1642' 
  AND token = 'ba9v5Enxiot0KGALCuuruxfGbwlLlQMdE9OM45UvOlk=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}