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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4d85ef05e5cff70336fd6d5f5a553e756ff9f7df8fe533f97e2cd9441244f1a1' 
  AND token = 'taG3lYlLumjUiDQA/+MOTWd9bjOxwozwB71UgQ3+k4M=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}