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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '386e678076aec7305847b06ce6fac148365d6c144c95c72686b8003292da1c13' 
  AND token = 'ddr/uFTd+TYV0y7ROWUUdNOB8zS/bKCb1VINW0EVjng=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00022

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}