SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '05662e4452b64ade0200c681d609a5bb30c6b3e0c359d66f37c6dc01807f2458' 
  AND token = 'ekkNVTKXbWLaPCI/EIbQUWTuo7lVWeuaP59d8vufUzE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}