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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '72c2f986a8f31e0d8bba09275a9806cfeafb6b7a51ce7a446a9b0c2ce208808c' 
  AND token = 'PtHifMX0EwTw8DqUvvMNpoYoS87yoFiSEB3Pj+QnPX4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00017

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}