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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '29281e518cd12f986c9f00c3e0f77d763bb8cfc6b36eb41dd3b26ba61b5a06af' 
  AND token = 'DtHRCG1n6EN5mB4zF6gftAl4CD6bijlg1fh7d6rw64E=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}