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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '1819d91c27dfe9154fafcea52c8d5275a7ae9d082cc917da957249b6a5bae728' 
  AND token = 'a5UMd2RwyBL78A11puc0VrFORYh161oiUU9LOKavsg8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}