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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4888a87da5803e3618e7d05317577b54c171e5d3bceed4e18fbee01921a22de8' 
  AND token = 'R9hfUMokeiXPd4Gp062IXn4kmqA+a0qZovepDQRtUr8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}