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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '377ec43090bd073b8e9eba35a33e1faacc1fe45e24b8f5f910699ac51f18f56f' 
  AND token = 'sUX08JdUmD/SOp0xeZUOFtLuMMBYZ9K7Xg8hW4brH9s=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00017

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}