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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '12cfe8980fde03f2ce00c0973b78b60b3dc22f5caf880bc0886bfcf4b8551e03' 
  AND token = 'EtuS28qqwP5xvs99fX4OarV0lye3kMyScmRFpsxigAI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}