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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'e22e2c57a76cbcd0408848cbc2c0bb008ea95d21cb709269eda329c5c6de9848' 
  AND token = 'UQgWb+S5q5m/HSkU2S+4EdMPxnz3oqYH1dtnEMRwj/0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00023

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}