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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '378df923365434982975d65a326c493bbfe4440ee122af0aef859ed98a757f75' 
  AND token = 'Zj33XcSB4lhQ1mz9n106Lbso9NBKn3WwCf1iWAGcW1o=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}