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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '42f96d1177c41f809410545c779f733d74fc8a9df5753765f89432e35445e131' 
  AND token = 'ESN1XqOkEhYpXXGD3UWHIKwrbpCXsz/bhs+nrWNFbPI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}