SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'b4742a144bc4c89a69dd219030803477eef428730866681b71014548440ea5ba' 
  AND token = 'O0Ah3PIVk2Y3fQq93PvSwenbDy+FasepvpJnUyOqw4g=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}