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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '3e1dc2942f05b3c4bad521ed9396bba9ad9b1955c05dd9f57360495914278603' 
  AND token = 'PrNcU4NuegrIbSd7axUD0grBPbAW1T6I+k4BulScdfo=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00017

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}