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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'e26a46dd07c4233b5ae8d78f59aebcb06025d9bcc960455c32e164a3c18e940e' 
  AND token = 'pqk/NGK4Y8GsdTzMwCB1C/af9T4mFYUB7zfOfqUoQRw=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}