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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4e27420d0a9e111357e15eb08670f04bc04a9f7d11378f4f3c134ed3d87aa337' 
  AND token = 'JeWNPqBAQPpchUqDVL8l1/emotuH+paWsoW2t2l+idg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}