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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'f1ea89ead63ef429fee0f5603d0666906b049a58dad46e9666067f29239adc68' 
  AND token = 'oT/vrAI8PZEqAv1uhYwiiVBQXf0Ev51vdZ1cSbdfB8I=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}