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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4ae28ff12abda6010d5169406310432d430e60c05e8b6f2e9b265dd75d4111ca' 
  AND token = 'k2cXHgCc/wgCw7w+tkdg+vfr3EqYdOsXT4bp2rBfjT0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00027

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}