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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '18278ce46d81065b4f88a0f4ba4d57afc3b3f5d92bb992ba5bab575f1dd8b514' 
  AND token = 'xvDgEH2BI5iK7M3EEu7dhvpnJeVrkJS4oLbSogeXyn8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}