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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '6d6b3b0a24cc0636ac658cdaea8ec0e55683a634aee388f6580fa57e8feefac8' 
  AND token = 'GkL26iGCRSnUA9h1HUp0A6/aTYJ2P4aT/zsz4c/Ikpw=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}