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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2c45a1516a62b899e80cca63f16381262f10e7fcf41cc5f564021f503da6d0d0' 
  AND token = 'jiPHAdokEIcHGOfG6qlsQBpoBzs4heSoTM1NQSo45uU=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}