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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '3d44c0e389b9b2643d16c145bd94fbeecc0dc037392861cde7591d7ce5ec35dd' 
  AND token = '/zXFtZzfS/vUeIOEgTxavqQ8sHRdFTa3nMfXWiJCjX4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}